Non sedating antihistimine

Posted by / 19-Jul-2017 14:15

Non sedating antihistimine

Main outcome measure: Reporting of sedation or drowsiness.Results: The odds ratios (adjusted for age and sex) for the incidence of sedation were 0.63 (95% confidence interval 0.36 to 1.11; P=0.1) for fexofenadine; 2.79 (1.69 to 4.58; P Antihistamines are often used to treat the symptoms of allergies such as seasonal and perennial allergic rhinitis and urticaria.These studies correlated prescriptions issued in general practice with events reported by the patients to their general practitioners after the drug was dispensed.By monitoring these events in a substantial population of allergy sufferers, without the restrictions imposed by clinical trials methodology, it was possible to measure differences in side effects between these drugs.

The pharmacist sends all these prescriptions to the Prescription Pricing Authority, which under conditions of full confidentiality, provides electronic copies of the exposure data to the Drug Safety Research Unit.The data collection periods for the four drugs were May to August 1989 for cetirizine and loratadine, May 1989 to September 1990 for acrivastine, and March to August 1997 for fexofenadine.The response rates (number of green forms returned/number of green form sent) were 50.7% for loratadine, 50.9% for fexofenadine, 56.5% for acrivastine, and 57.4% for cetirizine.The first generation antihistamines have been associated with side effects, particularly sedation.1 Second generation antihistamines are therefore favoured over the first generation drugs, not because of greatly improved efficacy but because they have fewer side effects, especially sedation.24 Although the second generation antihistamines are known to all have similar efficacy,3 the extent of their sedative effects is not well established.To further examine the sedative effects of four commonly prescribed antihistamines—loratadine, cetirizine, fexofenadine, and acrivastine—we analysed the results of four non-interventional observational cohort studies of these drugs performed by the Drug Safety Research Unit.

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